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PGD is a form of genetic diagnosis performed prior to implantation, so this is an adjunct to assisted reproductive technology, and always performed following an in vitro fertilization (IVF) cycle to obtain oocytes or fertilized embryos. In briefly, the procedure of PGD is consisted of the biopsy of one or two blastomeres from 4- to 8-cells-embryos and identification of a specific genetic defect using a fluorescent in situ hybridization (FISH) technique for chromosome adnormalities and mutation detection methods for a single gene disorder.

• Couples at risk for transmitting a specific genetic disease or abnormality to their offspring
• Carriers of AD and AR disorders
• Female carriers of X-linked disorders
• Carriers of balanced chromosome rearrangements (translocation and inversion)
• Some women having had multiple miscarriage
• Failed previous attempts at embryo transfer following IVF