Clinical & Basic Reaearch

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Basic Research Center

Over 250 papers have been published in local and international journals. The center has not only been awarded for the Best Paper in the American society for reproductive medicine (ASRM) and Korean society for reproductive medicine (KSRM) but was also nominated for the Best Paper for several times in ASRM and European society for reproductive medicine (ESHRE). Furthermore, CHA fertility center was introduced for three times in America’s leading news magazine, Times.

Basic research center of CHA medical center carries out genetic, infertility and other reproductive medicine researches. These researches are systematic and the center has been internationally recognized as a specialized reproductive research institute through all the research activities. The center is committed to represent as a specialized reproductive research institute in Korea for the 21st century by combining clinical and basic research in order to have more effective outcomes for infertility and genetic diseases.

1. Germ cells and cryobiology laboratory

Germ cells and cryobiology laboratory This laboratory is associated with Fertility Research Laboratory which takes responsibilities in the basic research related to infertility. Research on generation, differentiation and cryopreservation of oocytes and sperm are actively in progress related to stem cell research to overcome infertility. In addition, studies on fertilization of oocyte and sperm and subsequent early embryo development, and the establishment and differentiation of embryonic stem cell are under investigation.

Research areas

  • Discovery of spermatogenesis regulatory genes
  • Development of technology for in vitro sperm production from the stem cells
  • In vitro maturation and fertilization of oocytes
  • Cryopreservation of oocytes and sperm
  • Development of embryo culture condition
  • Establishment of embryonic stem cell and germ cell production, such as sperms and oocytes

2. Molecular reproductive physiology laboratory

Molecular reproductive physiology laboratory With the development of science and medicine, people’s life span lately became longer compare to that of the past decades. Despite of this change, the menopause comes in women (47~55 years old) at almost the same age. Thus, women undergo menopause longer during their life period. So far, the most accepted theory for the cause of menopause was that women uses limited number of ovarian primordial follicles during the reproductive period which consequently results in no ovulation due to depletion of primordial follicles.
We carried out researches regarding how the rest of primordial follicles remain arrested through the reproductive life while cohorts of primordial follicles were selected for growth.

Also we carried out studies on the follicle growth including growth of oocytes. Oocytes fertilize and equipped to have an ability to form embryos through the normal follicular development. Research on the mechanism oocyte maturation is still limited hence in our laboratory, we conducted research on this area in molecular biological aspects by using Genomics, Transcriptomics, Proteomics, and Bioinformatics.

Research areas

  • Research on genes and proteins related to regulation of follicular arrest and selection
  • Research on genes and proteins related to maturation process of immature oocytes
  • Research on the discovery of gene function by usihg RNA interference method

3. Stem cell laboratory

Molecular reproductive physiology laboratory Stem cell laboratory conducts research on human embryo stem (ES) cells, cell therapy development using human ES cells, establishment of new human ES cell lines and development of effective cryopreservation methods for ES cell preservation.
This laboratory also carries out research on the differentiation of ES cells to a specific germ layer using virus induced gene delivery system in order to apply it as a cell replacement therapy.


Research areas

  • Maintenance of human ES cells
  • Differentiation of mesodermal lineages from hESC
  • Differentiation of Osteoblastic Cells from HESC
  • Differentiation of Endothelial Cells from HESC
  • Differentiation of Genetic modification of human ES cells
  • Stable transgene expression in HESC using lentiviral gene delivery system